Those old trucks are huge and heavy bricks and they take power to push thru the air, and the faster you go, the worse it gets. So if you really want one of those, you are gonna have to figure out how to make it take less power to push it thru the air.
Here is some help; the rule of thumb is that it takes about a half a pound of gasoline to make one horsepower continuously for one hour.
Lets say that old truck might take 50 hp to maintain 60 mph. Therefor in 60 miles it will consume
50 x .5= 25 pounds of gas. At 6 pounds per gallon, that is
25/6= 4.17 gallons. The end result then is
4.17 gallons to 60 miles, or 14.4 mpg
But if you can aero that truck down, or lighten it up, to say a 40 hp requirement, then
60 miles /(40x.5)/6= 18 mpg.
But a better idea is to just start with a smaller lighter more aero truck at say 35hp requirement; then
60/(35x .5)/6=20.6 mpg
So now; you can begin to aero/lighten this truck to say a 30hp requirement or
60/(30 x .5)/6=24 mpg.
And finally;
Now you can start to "cheat " the above rule of thumb by;
Leaning out the cruise circuit, or
increasing the engines efficiency, or
reducing the number of cylinders, or
the number of cubic inches, or
the method of power transmission, or
by bringing down the rpm, or
installing EFI, or, or, or.....
So long as the engine can still physically cruise at 60 mph.
With a carb, a low-compression V8, and a 3speed auto trans, it's gonna be doggone hard to break into the 20s.
To help you get started, I suggest;
a 2-wheel drive,fuel-injected regular cab short-box, light-weight, first gen Dakota,with a 5-speed manual, or an A500 trans,and a hiway rpm of sub-2000. Then lighten it, lower it, modify the running gear so it rolls easy, and install tall, skinny, hard tires; at a million psi.
The engine can be just about anything if you are just looking for point to point economy because the hp requirement to cruise is the same, leaving just engine friction as the major difference, and, I guess, in that game,6 cylinders outta trump 8.
Of course any engine you use, will have to be in tip-top condition.
And the bigger the engine, the more fuel it will use when not cruising.
My money would be on the 5.2 Magnum.
Not all carburated engines are able to cruise well at sub 2000 rpm and it is impossible to give that engine the proper ignition timing, at sub-2000cruise rpm, with a factory distributor-type ignition system. So, you will have to spring for a programmable timing computer.
And just for kicks; you know how much headroom is in that cab? I'll guess 6 inches could be cut out with bucket seats, and that would reduce your frontal area by about 2.75 square feet! which maths out close to 10%. That is huge. Not sure what it would look like tho...............
BTW; the aftermarket makes fiberglass fenders and bedside panels for the 88 to 96 boxy models. It ain't much, but it's something,lol.